Staph aureus (coagulase positive) to be most frequent causative organisms causing cavernous sinus thrombosis. Thrombosis of cavernous sinus may be acute or chronic. This may be categorised into anterior and posterior verities. Spread of infection from the face and mouth is by anterior route by way of the facial vein through the angular vein and the superior ophthalmic vein and from the ear or mastoid the posterior route through the afferent veins of the cavernous sinus. The anterior variety represents the acute and fulminating infections. The posterior variety is due to retrograde propogation of a thrombus via the dual venous sinuses. Heparin is used in the treatment of cavernous sinus thrombosis. The rationale of anticoagulants is to stop (1) further thromobosis of the venous sinuses and thus to prevent further interference with the venous drainage of the brain and dissemination of spetic emboli with the formation of widespread miliary abscesses. The coumarin derivatives have also been utilized for anticoagulation. Patient faces endless complications. Fragments of infected emboli may pass down the jugular veins and lead to pulmonary embolism characterized by pain in the chest and development of signs of pneumonia or pleurisy.