Incidence of renal glomerular disease in Pakistan is not exactly known. This may be attributed to (a) lack of interest in thoroughly investigating patients for renal diseases of both primary and secondary nature, (b) inadequate laboratory facilities, and the lack of close co-operation between clinicians and pathologists, and (c) a widely practised method of blind_ therapy in patients showing only preliminary biochemical evidence of renal disease, which ought to be confirmed, by the histological examination of renal biopsy. Proper diagnosis of renal glomerular disease in Pakistan is needed because malaria and typhoid being endemic diseases could be responsible for renal disease in at least a certain percentage of patients.