The commonest organism responsible for bone infection Staphylococcus aureus and the most effective drugs in bone Infection were Kanamycin, Kanacillin, cloxacillin Lincomycin, capreomycin, Novobiocin, nitrofuranton, chloramphenicol and co-trimoxazole. In most of the areas of our country, the culture sensitivity facilities are not easily available. It has to be decided by the clinician what to give to a patient with acute osteomylitis. The drugs of choice should be Kanacillin, cloxacillin, novobiocin, Co-trinoxazole and Chloramphenicol.