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Generalized cutaneous granulocytic sarcoma with joint involvement

Author(s)
Samina Mansoor Department of Pathology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan
Nasir-ud-Din Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan
Muhammad Azam Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan
Arif Jamshed Department of Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan
Abstract
Granulocytic sarcoma (GS) is a rare extra medullary solid tumour composed of immature myeloid cells. These tumours often display a greenish colour due to the enzymatic action of myeloperoxidase in the tumour cells. Hence, the term 'chloroma' was given to this lesion in 1853. GS commonly involves bone, periosteum, soft tissue, lymph node, and skin. Rare occurrences in muscle, meninges, breast, mediastinum, joints and ovary have been reported. Below-knee joint involvement in GS is unusual. We report a case of generalized cutaneous granulocytic sarcoma with ankle joint involvement who subsequently developed AML-M4.
Publication Details
Page(s) 339-340
DOI DOI not available
Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 20, Issue: 5, Year: 2010

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Keywords
Granulocytic sarcoma. Myeloid peroxidase. Myeloblasts. Ankle joint.
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