Comparison between adrenaline and without adrenaline solution on bleeding control of skin graft donor site: a randomized controlled trial

Mahak Ali; Hyder Ali; Faisal Akhlaq Ali; Faraz Adil; Urooj Ali; Samia Tasleem

doi:10.35845/kmuj.2022.22064

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Comparison between adrenaline and without adrenaline solution on bleeding control of skin graft donor site: a randomized controlled trial

Author(s)

Mahak Ali Department of Plastic and Reconstructive Surgery, Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan.

Hyder Ali Department of Plastic and Reconstructive Surgery, Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan.

Faisal Akhlaq Ali Department of Plastic and Reconstructive Surgery, Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan.

Faraz Adil Department of Plastic and Reconstructive Surgery, Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan.

Urooj Ali Department of Plastic and Reconstructive Surgery, Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan.

Samia Tasleem Department of Plastic and Reconstructive Surgery, Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan.

Abstract

OBJECTIVE: To compare the bleeding control of skin graft donor site between normal saline soaked gauze with adrenaline and conventional technique having no adrenaline. METHODS: This open-label randomized control trial was conducted at Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan from October 2020 to March 2021. Seventy-five patients were randomized to interventional (n=36, 48%) and control group (n=39, 52%) through sealed envelopes. Diluted solution was prepared by adding 30cc of Ringer's lactate and 10cc of lignocaine 2%, with 1cc of adrenaline of 1:200000 with 200 ml of normal saline solution. Solution for control group was containing only normal saline. Following the skin harvesting at donor site, a gauze piece soaked with tumescent solution was applied at the donor site wound. Bleeding severity and epithelialization were assessed. Data was recorded in a pre-designed performa and analyzed through SPSS version-25. RESULTS: There was no significant differences in baseline characteristics like age (p=0.823), gender (p=0.984) and nature of injury (p=0.936) among two groups. Severe, moderate and mild bleeding was noted in 20/39 (51.3%), 15/39 (38.5%) and 4/39 (10.3%) cases in control group as compared to 0/36 (0%); 2/36 (5.6%) and 25/36 (69.4%) cases in interventional group respectively (**<0.001). No bleeding was noted in 9/36 (25%) cases of interventional group. Complete epithelialization was observed in 24/36 (66.7%) & 17/39 (43.6%) cases in adrenaline and control groups respectively (p=0.045). CONCLUSION: Application of adrenaline was more effective in bleeding control and early epithelialization at donor site following the skin harvesting as compared to conventional technique.

Publication Details

Page(s) 5-10

DOI 10.35845/kmuj.2022.22064

Published Journal: Khyber Medical University Journal, Volume: 14, Issue: 1, Year: 2022

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Keywords

Surgery, Pakistan (MeSH), Vasoconstrictor Agents (MeSH), Hemostasis (MeSH), Plastic (MeSH), Epinephrine (MeSH), Adrenaline (MeSH), Skin-graft (Non-MeSH), Tissue Transplantation (MeSH), Donor site (Non MeSH), Karachi (Non-MeSH), Reconstructive Surgical Procedures (MeSH), Transplant Donor Site (MeSH), Transplantation (MeSH)

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