Background: To assess the effects of Rocuronium pretreatment on Succinylcholine induced rise in serum potassium. Methods: In this randomized controlled experimental during depolarization. Severe hyperkalemia after study, sixty adults ASA I or II patients who presented for succinylcholine resulting in cardiac arrest has also eplaetciteinvtes gweenreeradlivsiudregdicainl pt wroocegdruoruepss woefrethiirntcyluedaechd. bTyhea been observed in acidotic hypovolemic patients.1-3 simple randomization. Group "A" received succinylcholine To minimize the hyperkalemia associated with and group "B" received precurarization dose of rocuronium succinylcholine administration, investigators have followed by succinylcholine for intubation. Venous blood tried pretreatment with various drugs, including samples were obtained for estimation of serum potassium nondepolarizing neuromuscular relaxants, (K+) at 0 minutes and after five minutes of intubation. flunitrazepam, diazepam, and magnesium sulfate with mixed results . Administration of non depolarizing Results: There was a significant rise in serum K+ level neuromuscular blocker before administration of from the start of the study to five minutes in group A (p < succinylcholine is effective in reducing the increase in 0.001). In group B, increase in serum K+ level from start of serum K+ concentration. Pretreatment with a trhemeastiundedy twoitfhivine mthienuntoersmwalasrasniggne.ifTichaentin(pcre=a0se.00in1)sbeurut mit nondepolarizing neuromuscular relaxant or diazepam K+ level was significantly more in group A as compared to to minimize succinylcholine-induced hyperkalemia group B (p < 0.001). may also be considered in the clinical setting. 5 Rocuronium bromide, a new non-depolarizing Conclusion: Pretreatment with rocuronium prevents aminosteroidal muscle relaxant is a derivative of the rise in serum potassium induced by succinylcholine.