Synthesis, characterization, crystal structures, analgesic and antioxidant activities of Thiourea derivatives.

Mohammad Shoaib; Shafiullah; Muhammad Ayaz; Muhammad Nawaz Tahir; Syed Wadood Ali Shah

No Detail Found!

Synthesis, characterization, crystal structures, analgesic and antioxidant activities of Thiourea derivatives.

Author(s)

Mohammad Shoaib Department of Pharmacy, University of Malakand, Chakdara Dir Lower, Khyber Pakhtunkhwa, Pakistan

Shafiullah Department of Pharmacy, University of Malakand, Chakdara Dir Lower, Khyber Pakhtunkhwa, Pakistan

Muhammad Ayaz Department of Pharmacy, University of Malakand, Chakdara Dir Lower, Khyber Pakhtunkhwa, Pakistan

Muhammad Nawaz Tahir Department of Physics, University of Sargodha, Sargodha, Pakistan

Syed Wadood Ali Shah Department of Pharmacy, University of Malakand, Chakdara Dir Lower, Khyber Pakhtunkhwa, Pakistan

Abstract

1-(2-chlorobenzoy1)-3(2,3-dimethyl-5-oxo-l-phenyl-2,F-dihydro-1H-pyrazo1-4-yl) thiourea (Cl2AAP) and 1-(2-chlorobenzoyl)-3-(pyridine-2-yl)thiourea (Cl2AP) were synthesized and characterized by spectroscopic methods (FT-IR, 1H NMR) and single crystal X-ray diffraction. Both compounds crystallized in monoclinic system and solved in P21/n, Z = 4 and P21/C, Z = 12 space groups respectively. Pharmacological screenings of the synthesized compounds have shown comparable analgesic activity to that of the standard diclofenac sodium at 30 mg/kg body weight dose. The DPPH and ABTS free radical scavenging activity of Cl2AAP are more significant than Cl2AP as compared to standard (IC50= 10, 60; 45, 75; and

Publication Details

Page(s) 479-486

DOI DOI not available

Published Journal: Journal of Chemical Society of Pakistan, Volume: 38, Issue: 3, Year: 2016

Request the full text from PASTIC

Citations

Downloads

Views