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Synthesis, characterization and RP-HPLC method development and validation for simultaneous determination of Koch acid and H acid.

Author(s)
Syed Ahmad Raza Bokhari Government College, University, Lahore, Pakistan
Rana Rashad Mahmood Khan Government College, University, Lahore, Pakistan
Muhammad Saqlain Tahir Government College, University, Lahore, Pakistan
Naveed Tahir M.N. Chemicals Ltd. Faisalabad, Pakistan
Quratulain Syed PCSIR Labs Complex, Lahore Pakistan
Ahmad Adnan Government College, University, Lahore, Pakistan
Abstract
1-amino-8-naphthol-3,6-disulfonic acid (H acid) is an important intermediate used for the synthesizing some dyestuffs and pharmaceuticals. The synthesis of H acid was followed by sulfonation, nitration, reduction and alkali fusion. The total yield was increased to 35% with 99% purity. This study focuses on cheap synthesis of H acid on an industrial scale. The composition and percentage of these compounds were characterized by making reactive dyes and chromatographic analysis, i.E. UV/Visible, IR and HPLC. The RP-HPLC method was developed; in the analysis of Koch acid (1-amino-naphthalene-3,6,8-trisulfonic acid) and H acid. The single HPLC method is useful, both, in the chemical intermediate (Koch acid) and for the final product (H acid).
Publication Details
Page(s) 469-478
DOI DOI not available
Published Journal: Journal of Chemical Society of Pakistan, Volume: 38, Issue: 3, Year: 2016

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