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Subclinical-hypothyroidism: a Pathology in Evolution.

Author(s)
Sikandar Hayat Khan Department of Pathology, PNS Hafeez, Islamabad, Pakistan
Aamir Ijaz Department of Chemical Pathology and Clinical Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan
Abstract
Subclinical-hypothyroidism is identified as suboptimal thyroid hormonal production associated with mild TSH (thyroid stimulating hormone) elevation. Though several non-thyroidal illness in the later stages, medications and dietary supplements may resemble SCH (subclinical-hypothyroidism), but mild persistent subnormal thyroidal pathologies are usually termed as SCH. This review briefly describes the various cardiovascular risk associations with subclinicalhypothyroidism and attempts to provide an insight into the risk and benefit association, which a patient faces once treated for SCH.
Publication Details
Page(s) 150-158
DOI DOI not available
Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 29, Issue: 2, Year: 2019

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References
SurksMI,OrtizE,DanielsGH,SawinCT,ColNF,CobinRH, 2004.Subclinical thyroid disease: scientific review and guidelines for diagnosis and management,JAMA 291 228 -38
HollowellJG,StaehlingNW,FlandersWD,HannonWH,GunterEW,SpencerCA, 2002.National health and nutrition examination survey (NHANES III),J Clin Endocrinol Metab 87 489 -99
TunbridgeWM,EveredDC,HallR,AppletonD,BrewisM,ClarkF, 1977.The spectrum of thyroid disease in a community: the Whickham survey,ClinEndocrinol (Oxf) 7 481 -93
VerburgFA,KirchgässnerC,HebestreitH,SteigerwaldU,LentjesEG,ErgezingerK, 2011.Reference ranges for analytes of thyroid function in children,HormMetab Res 43 422 -6
JonklaasJ,BiancoAC,BauerAJ,BurmanKD,CappolaAR,CeliFS, 2014.Guidelines for the treatment of hypothyroidism: Prepared by the American thyroid association task force on thyroid hormone replacement,Thyroid 24 1670 -751
Herter-AeberliI,CherkaouiM,El AnsariN,RohnerR,StincaS,ChabaaL, 2015.Iodine supplementation decreases hypercholesterolemia in iodine-deficient, overweight women: A randomized controlled trial,J Nutr 145 2067 -75
AlibazOnerF,YurdakulS,OnerE,Kubat UzumA,ErguneyM, 2011.Evaluation of the effect of L-thyroxin therapy on endothelial functions in patients with subclinicalhypothyroidism,Endocrine 40 280 -4
KowalskaI,BorawskiJ,NikolajukA,BudlewskiT,OtziomekE,GórskaM, 2011.Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinicalhypothyroidism: Response to levothyroxine therapy,Endocrine 40 95 -101
SathyapalanT,ManuchehriAM,ThatcherNJ,RigbyAS,ChapmanT,KilpatrickES, 2011.The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinicalhypothyroidism: a randomized, double-blind, crossover study,J Clin Endocrinol Metab 96 1442 -9
ShakoorSK,AldibbiatA,IngoeLE,CampbellSC,SibalL,ShawJ, 2010.Endothelial progenitor cells in subclinicalhypothyroidism: the effect of thyroid hormone replacement therapy,J Clin Endocrinol Metab 95 319 -22
AdreesM,GibneyJ,El-SaeityN,BoranG., 2009.Effects of 18 months of L-T4 replacement in women with subclinicalhypothyroidism,Clin Endocrinol (Oxf) 71 298 -303
MikhailGS,AlshammariSM,AleneziMY,MansourM,KhalilNA, 2008.Increased atherogenic low-density lipoprotein cholesterol in untreated subclinical-hypothyroidism,Endocr Pract 14 570 -5
CanarisGJ,ManowitzNR,MayorG,RidgwayEC, 2000.The Coloradothyroid disease prevalence study,Arch Intern Med 160 526 -34
GarberJR,CobinRH,GharibH,HennesseyJV,KleinI,MechanickJI, 2012.American association of clinical endocrinologists and American thyroid association taskforce on hypothyroidism in adults. Clinical practice guidelines for hypothyroidism in adults: co-sponsored by the American association of clinical endocrinologists and the American thyroid association,Endocr Pract 18 988 -1028
RadettiG,MaselliM,BuziF,CorriasA,MussaA,CambiasoP, 2012.The natural history of the normal/mild elevated TSH serum levels in children and adolescents with Hashimoto's thyroiditis and isolated hyperthyrotropinaemia: a 3-year followup? Clin Endocrinol (, 76 394 -8
RadettiG,GottardiE,BonaG,CorriasA,SalardiS,LocheS., 2006.The natural history of euthyroid Hashimoto's thyroiditis in children,J Pediatr 149 827 -32
SmitJW,Eustatia-RuttenCF,CorssmitEP,PereiraAM,FrölichM,BleekerGB, 2005.Reversible diastolic dysfunction after longterm exogenous subclinical hyperthyroidism: A randomized, placebo-controlled study,J Clin Endocrinol Metab 90 6041 -7
AuerJ,ScheibnerP,MischeT,LangstegerW,EberO,EberB, 2001.Subclinical-hyperthyroidism as a risk factor for atrial fibrillation,Am Heart J 142 838 -42
CaseyBM,DasheJS,WellsCE,McIntireDD,LevenoKJ,CunninghamFG, 2006.Subclinical hyperthyroidism and pregnancy outcomes,Obstet Gynecol 107 337 -41
AtkinsP,CohenSB,PhillipsBJ, 2000.Drug therapy for hyperthyroidism in pregnancy: safety issues for mother and fetus,Drug Saf 23 229 -44
ChenJL,ChiuHW,TsengYJ,ChuWC, 2006.Hyperthyroidism is characterized by both increased sympathetic and decreased vagal modulation of heart rate: evidence from spectral analysis of heart rate variability,Clin Endocrinol (Oxf) 64 611 -6
CeresiniG,LauretaniF,MaggioM,CedaGP,MorgantiS,UsbertiE, 2009.Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study,J Am Geriatr Soc 57 89 -93
BrennanMD,PowellC,KaufmanKR,SunPC,BahnRS,NairKS, 2006.The impact of overt and subclinical-hyperthyroidism on skeletal muscle,Thyroid 16 375 -80
De RosaG,TestaA,GiacominiD,CarrozzaC,AstaziP,CaradonnaP, 1997.Prospective study of bone loss in pre- and postmenopausal women on L-thyroxine therapy for non-toxic goitre,Clin Endocrinol (Oxf) 47 529 -35
BelayaZE,MelnichenkoGA,RozhinskayaLY,FadeevVV,AlekseevaTM,DorofeevaOK, 2007.Subclinical-hyperthyroidism of variable etiology and its influence on bone in postmenopausal women,Hormones 6 62 -70
SchneiderR,ReinersC., 2003.The effect of levothyroxine therapy on bone mineral density: a systematic review of the literature,Exp Clin Endocrinol Diabetes 111 455 -70
GreenspanSL,GreenspanFS,ResnickNM,BlockJE,FriedlanderAL,GenantHK, 1991.Skeletal integrity in premenopausal and postmenopausal women receiving long-term L-thyroxine therapy,Am J Med 91 5 -14
2003.Thyroid hormones: beneficial or deleterious for bone?,Calcif Tissue Int 73 205 -9
Kasperlik-ZaluskaA,CzarnockaB,CzechW., 1994.High prevalence of thyroid autoimmunity in idiopathic Addison's disease,Autoimmunity 18 213 -6
TaylorPN,IqbalA,MinassianC,SayersA,DramanMS,GreenwoodR, 2014.Falling threshold for treatment of borderline elevated thyrotropin levels - balancing benefits and risks: evidence from a large community-based study,JAMA Intern Med 174 32 -9
RazviS,WeaverJU,VanderpumpMP,PearceSH, 2010.The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: Re-analysis of the Whickham Survey cohort,J Clin Endocrinol Metab 95 1734 -40
GencerB,ColletTH,VirginiV,BauerDC,GusseklooJ,CappolaAR, 2012.Thyroid studies collaboration. Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts,Circulation 126 1040 -9
McQuadeC,SkugorM,BrennanDM,HoarB,StevensonC,HoogwerfBJ, 2011.Hypothyroidism and moderate subclinical hypothyroidism are associated with increased all-cause mortality independent of coronary heart disease risk factors: a PreCIS database study,Thyroid 21 837 -43
OchsN,AuerR,BauerDC,NanchenD,GusseklooJ,CornuzJ, 2008.Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality,Ann Intern Med 148 832 -45
2007.Thyroid function and carotid artery intima-media thickness,Circ J 71 993 -
IqbalA,JordeR,FigenschauY., 2006.Serum lipid levels in relation to serum thyroid-stimulating hormone and the effect of thyroxine treatment on serum lipid levels in subjects with subclinical hypothyroidism: the Tromsø study,J Intern Med 260 53 -61
LiuC,ScherbaumWA,SchottM,Schinner S, 2011.Subclinicalhypothyroidism and the prevalence of the metabolic syndrome,Horm Metab Res 43 417 -21
VyakaranamS,VanaparthyS,NoriS,PalarapuS,BhongirAV, 2014.Study of insulin resistance in subclinical-hypothyroidism,Int J Health Sci Res 4 147 -53
GarberJR,CobinRH,GharibH,HennesseyJV,KleinI,MechanickJI, 2012.American association of clinical endocrinologists and American thyroid association taskforce on hypothyroidism in adults. Clinical practice guidelines for hypothyroidism in adults: co-sponsored by the American association of clinical endocrinologists and the American thyroid association,Thyroid 22 1200 -35
Bocos-TerrazJP,Izquierdo-AlvarezS,Bancalero-FloresJL,Alvarez-LahuertaR,Aznar-SaucaA,Real-LópezE, 2009.Thyroid hormones according to gestational age in pregnant Spanish women,BMC Res Notes 2 237 -
ChenLM,DuWJ,DaiJ,ZhangQ,SiGX,YangH, 2014.Effects of subclinical hypothyroidism on maternal and perinatal outcomes during pregnancy: A single-center cohort study of a Chinese population,PLoS One 9 e109364 -
VanderpumpMP,TunbridgeWM,FrenchJM,AppletonD,BatesD,ClarkF, 1995.The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham survey,Clin Endocrinol (Oxf) 43 55 -68
WalshJP,BremnerAP,FeddemaP,LeedmanPJ,BrownSJ,O'LearyP., 2010.Thyrotropin and thyroid antibodies as predictors of hypothyroidism: A 13-year, longitudinal study of a communitybasedcohort using current immunoassay techniques,J Clin Endocrinol Metab 95 1095 -104
StriederTG,TijssenJG,WenzelBE,EndertE,Wiersinga WM, 2008.Prediction of progression to overt hypothyroidism or hyperthyroidism in female relatives of patients with autoimmune thyroid disease using the Thyroid Events Amsterdam (THEA) score,Arch Intern Med 168 1657 -63
KorzeniowskaK,Jarosz-ChobotP,SzypowskaA,RamotowskaA,FendlerW,Kalina-FaskaB, 2013.L-thyroxine stabilizes autoimmune inflammatory process in euthyroidnongoitrous children with Hashimoto's thyroiditis and type 1 diabetes mellitus,J Clin Res Pediatr Endocrinol 5 240 -4
BalázsC., 2012.The role of hereditary and environmental factors in autoimmune thyroid diseases,Orv Hetil 153 1013 -22
FortiP,OlivelliV,RiettiE,MaltoniB,PirazzoliG,GattiR, 2012.Serum thyroid-stimulating hormone as a predictor of cognitive impairment in an elderly cohort,Gerontology 58 41 -9
HogervorstE,HuppertF,MatthewsFE,BrayneC,AgeingStudy, 2008.Thyroid function and cognitive decline in the MRC Cognitive Function,Psychoneuroendocrinology 33 1013 -22
BashirH,BhatMH,FarooqR,MajidS,ShoibS,HamidR, 2012.Comparison of hematological parameters in untreated and treated subclinical hypothyroidism and primary hypothyroidism patients,Med J Islam Repub Iran 26 172 -8
RavanbodM,AsadipooyaK,KalantarhormoziM,NabipourI,OmraniGR, 2013.Treatment of iron-deficiency anemia in patients with subclinical hypothyroidism,Am J Med 126 420 -4
CanpolatAG,KavT,SivriB,Yildiz BO, 2013.Effects of L-thyroxine on gastric motility and ghrelin in subclinicalhypothyroidism: a prospective study,J Clin Endocrinol Metab 98 E1775 -9
KimEO,LeeIS,ChoiYA,LeeSJ,ChangYK,YoonHE, 2013.Unresolved subclinical hypothyroidism is independently associated with progression of chronic kidney disease,Int J Med Sci 11 52 -9
ShinDH,LeeMJ,LeeHS,OhHJ,KoKI,KimCH, 2013.Thyroid hormone replacement therapy attenuates the decline of renal function in chronic kidney disease patients with subclinical hypothyroidism,Thyroid 23 654 -61
PoppeK,GlinoerD,TournayeH,ManiewskiU,HaentjensP,VelkeniersB, 2006.Is systematic screening for thyroid disorders indicated in subfertile men?,Eur J Endocrinol 154 363 -6
PeiYJ,WangAM,ZhaoY,YanL,LiM,WhiteRE, 2014.Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism,Gynecol Endocrinol 30 553 -6
YoshiokaW,AminoN,IdeA,KangS,KudoT,NishiharaE, 2015.Thyroxine treatment may be useful for subclinical hypothyroidism in patients with female infertility,Endocr J 62 87 -92
GulserenS,GulserenL,HekimsoyZ,CetinayP,OzenC,TokatliogluB.,Depression, 2006.-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction,Arch Med Res 37 133 -9
HickieI,BennettB,MitchellP,WilhelmK,OrlayW., 1996.Clinical and subclinical-hypothyroidism in patients with chronic and treatment-resistant depression,Aust N Z J Psychiatry 30 246 -52
AyersS,SwitnickiMP,AngajalaA,LammelJ,ArumanayagamAS, 2014.Genome-wide binding patterns of thyroid hormone receptor beta,PLoS One 9 e81186 -
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