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Establishing Age Specific Spirometry Reference Ranges for Children/adolescents of Karachi, Pakistan: Randomized Trials.

Author(s)
Sara Sadiq Ziauddin University, Karachi, Pakistan
Syed Tousif Ahmed Ziauddin University, Karachi, Pakistan
Nadeem Ahmed Rizvi Jinnah Postgraduate Medical Centre (JPMC), Karachi,
Farah Ahmed Ziauddin University, Karachi, Pakistan
Abstract
Objectives: To establish age-specific normative spirometry reference range along with regression equation for children and adolescents. Methods: The cross-sectional study was conducted from April to October 2017, and comprised children and adolescents aged 7-18 years at 8 educational institutions representing various socio-economic strata of Karachi. A modified version of the International Study of Asthma and Allergies in Childhood Questionnaire was used. Spirometry variables including forced vital capacity, forced expiratory volume in 1 second, ratio between the two, peak expiratory flow rate, forced expiratory flow between 25% and 75% expired volume were recorded and interpreted. By normal distribution curve the reference values were established, and mean ±2 standard deviation values were taken as significant. Pearson's correlation coefficient and linear regression models were calculated for all pulmonary variables with age. Results: Of the 751 subjects, 484(64.4%) were boys and 267(35.5%) were girls. The overall mean age was 12.96±2.8 years. The mean lung volume for forced vital capacity was 2.21±0.75, forced expiratory volume in 1 second 2.08±0.73, ratio between the two 92.9±4.7, peak expiratory flow 231.3 ± 70.5 and forced expiratory flow between 25% and 75% expired volume was , , , 2.68±1.2. These lung volumes directly increased with age from children to adolescents (p<0.05). All variables showed a significant difference between boys and girls (p<0.05). Conclusion: There was a linear positive correlation of age with lung function variables, while the boys presented higher values than the girls.
Publication Details
Page(s) 24-28
DOI DOI not available
Published Journal: Journal of Pakistan Medical Association, Volume: 69, Issue: 1, Year: 2019

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Keywords
Spirometry, Forced vital capacity, forced expiratory volume, Regression analysis.
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