Olfactory Change Pattern after Endoscopic Sinus Surgery in Chronic Rhinosinusitis with Olfactory Dysfunction.

XiaoXue Zi; LiLi Zhi; Peng Jin; HuiWei Feng; Li Zhao; YanYi Tu; Li Shi

Author(s)

XiaoXue Zi Department of Otolaryngology, The Second Affiliated Hospital, Shandong University, China

LiLi Zhi Department of Otolaryngology, Central Hospital of ZiBo, China

Peng Jin Department of Otolaryngology, The Second Affiliated Hospital, Shandong University, China

HuiWei Feng Department of Otolaryngology, The Second Affiliated Hospital, Shandong University, China

Li Zhao Department of Otolaryngology, The Second Affiliated Hospital, Shandong University, China

YanYi Tu Department of Otolaryngology, The Second Affiliated Hospital, Shandong University, China

Li Shi Department of Otolaryngology, The Second Affiliated Hospital, Shandong University, China

Abstract

Objective: To determine the change pattern of olfactory function in chronic rhinosinusitis (CRS) with olfactory dysfunction after endoscopic sinus surgery (ESS), and its association with inspection scores. Study Design: Observational study. Place and Duration of Study: Second Hospital of Shandong University, China, from December 2014 to January 2016. Methodology: Thirty-four CRS with nasal polyps (CRSwNP) patients and 14 CRS without nasal polyps (CRSsNP) patients were evaluated preoperatively by T&T olfactory test, olfactory VAS test, SNOT-20 score and Lund-Mackay CT score. Outcomes were re-evaluated at 1 month, 3 months and 6 months postoperatively. Results: Both olfactory and SNOT-20 scores showed significant improvement within 6 months in both CRSwNP and CRSsNP groups. Patients with anosmia in T&T test showed the largest degree of improvement. No significant recovery of olfactory dysfunction was observed at 1 month and 3 months in CRSsNP groups postoperative. In CRSwNP, the olfactory scores were correlated with the CT scores significantly (r=0.649, p<0.001; r=0.625, p<0.001). However, no correlation was found between the SNOT-20 score and olfactory score preoperatively. Conclusion: Our study has confirmed that the therapeutic effects of ESS on olfactory function last for up to 6 months, particularly in patients with CRSwNP. Although the therapeutic effects plateaued at 3 months postoperatively, the olfactory function continues to recover between 3 and 6 months.

Publication Details

Page(s) 612-617

DOI DOI not available

Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 28, Issue: 8, Year: 2018

Request the full text from PASTIC

References

FokkensWJ,LundVJ,MullolJ,BachertC,AlobidI,BaroodyF, 2012.,European position paper on rhinosinusitis and nasal polyps 2012. Rhinol Suppl 3 1 -298

ShiJB,FuQL,ZhangH,ChengL,WangYJ,ZhuDD, 2015.Epidemiology of chronic rhinosinusitis: results from a crosssectional survey in seven Chinese cities,Allergy 70 533 -9

AltJA,MaceJC,BunielMC,SolerZM,SmithTL, 2014.Predictors of olfactory dysfunction in rhinosinusitis using the brief smell identification test,Laryngoscope 124 E259 -66

LevyJM,MaceJC,SansoniER,SolerZM,SmithTL, 2016.Longitudinal improvement and stability of olfactory function in the evaluation of surgical management for chronic rhinosinusitis,Int Forum Allergy Rhinol 6 1188 -95

LitvackJR,FongK,MaceJ,JamesKE,SmithTL, 2008.Predictors of olfactory dysfunction in patients with chronic rhinosinusitis,Laryngoscope 118 2225 -30

TemmelAF,QuintC,Schickinger-FischerB,KlimekL,StollerE,HummelT, 2002.Characteristics of olfactory disorders in relation to major causes of olfactory loss,Arch Otolaryngol Head Neck Surg 128 635 -41

HongSM,ParkIH,KimKM,ShinJM,LeeHM, 2011.Relationship between the Korean version of the sniffin' stick test and the T&T olfactometer in the Korean population,Clin Exp Otorhinolaryngol 4 184 -7

KernRC,ConleyDB,HainesGK,RobinsonAM, 2004.Pathology of the olfactory mucosa: implications for the treatment of olfactory dysfunction,Laryngoscope 114 279 -85

LundVJ,KennedyDW, 1997.Staging for rhinosinusitis,Otolaryngol Head Neck Surg 117 S35 -40

TakagiSF, 1987.A standardized olfactometer in Japan. A review over ten years,Ann N Y Acad Sci 510 113 -8

TakebayashiH,TsuzukiK,OkaH,FukazawaK,DaimonT,SakagamiM., 2011.Clinical availability of a self-administered odor questionnaire for patients with olfactory disorders,Auris Nasus Larynx 38 65 -72

LimM,Lew-GorS,DarbyY,BrookesN,ScaddingG,LundVJ, 2007.The relationship between subjective assessment instruments in chronic rhinosinusitis,Rhinology 45 144 -7

PiccirilloJF,MerrittMG,RichardsML, 2002.Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20),Otolaryngol Head Neck Surg 126 41 -7

HarunaS,OtoriN,MoriyamaH,NakanishiM,Haruna S, 2006.Olfactory dysfunction in sinusitis with infiltration of numerous activated eosinophils,Auris Nasus Larynx 33 23 -30

LitvackJR,MaceJC,SmithTL, 2009.Olfactory function and disease severity in chronic rhinosinusitis,Am J Rhinol Allergy 23 139 -44

KimDW,KimJY,JeonSY., 2011.The status of the olfactory cleft may predict postoperative olfactory function in chronic rhinosinusitis with nasal polyposis,Am J Rhinol Allergy 25 e90 -4

BramersonA,NordinS,BendeM., 2007.Clinical experience with patients with olfactory complaints, and their quality of life,Acta Otolaryngol 127 167 -74

MiwaT,FurukawaM,TsukataniT,CostanzoRM,DiNardoLJ,ReiterER, 2001.Impact of olfactory impairment on quality of life and disability,Arch Otolaryngol Head Neck Surg 127 497 -503

HopkinsC,BrowneJP,SlackR,LundV,BrownP., 2007.The LundMackay staging system for chronic rhinosinusitis: how is it used and what does it predict?,Otolaryngol Head Neck Surg 137 555 -61

WabnitzDA,NairS,WormaldPJ, 2005.Correlation between preoperative symptom scores, quality-of-life questionnaires, and staging with computed tomography in patients with chronic rhinosinusitis,Am J Rhinol 19 91 -6

LindH,JoergensenG,LangeB,SvendstrupF,KjeldsenAD, 2016.Efficacy of ESS in chronic rhinosinusitis with and without nasal polyposis: a Danish cohort study,Eur Arch Otorhinolaryngol 273 911 -9

Citations

Downloads

Views