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Lung Cancer with Concomitant Double Gene Mutation.

Author(s)
Tao Fan Department of Oncology, Three Gorges University People's Hospital, the First People's Hospital of Yichang, Xiling District, Yichang City, Hubei-443000, China
XiuLi Liu Department of Oncology, Three Gorges University People's Hospital, the First People's Hospital of Yichang, Xiling District, Yichang City, Hubei-443000, China
Jun Zhou Department of Oncology, Three Gorges University People's Hospital, the First People's Hospital of Yichang, Xiling District, Yichang City, Hubei-443000, China
YingJie Song Department of General Surgery, Three Gorges University People's Hospital, the First People's Hospital of Yichang, Xiling District, Yichang City, Hubei-443000, China
Hong Yang Department of Oncology, Three Gorges University People's Hospital, the First People's Hospital of Yichang, Xiling District, Yichang City, Hubei-443000, China
YaNan Wei Department of Oncology, Three Gorges University People's Hospital, the First People's Hospital of Yichang, Xiling District, Yichang City, Hubei-443000, China
Abstract
A patient presenting with concomitant epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) translocation is very rare. We report a non-small cell lung cancer (NSCLC) patient with concomitant EGFR (exon 19-del) mutation and ALK rearrangement. The positron emission tomography-computed tomography (PET-CT) scan revealed a highly metabolic mass lesion in the left lower lobe, measured 5.0 cm in the largest dimension in the S6 segment. Transbronchial lung biopsy (TBLB) showed the pathological diagnosis of invasive adenocarcinoma. Thus, the patient underwent left lower lobectomy and hilar-mediastina lymph node dissection (pT2N0M0). The tumor harbor an ALK (D5F3 +) rearrangement and EGFR (exon 19-del) mutation. The patient initially received four cycles of chemotherapy (pemetrexed and carboplatin), and achieved partial response (PR).
Publication Details
Page(s) 72-73
DOI DOI not available
Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 28, Issue: 1, Year: 2018

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