To investigate the different factors affecting the performance of top most students at university level, and to compare the perception and significant differences between the male and female students, the present study was conducted by taking a sample of 120 students at University level. Primary data were collected on various factors like student’s involvement in their study, role conflict, student’s concern regarding study quality, fellow relationship, autonomy in their study and environmental indulgence. Counts, percentages and mean average score (MAS) were used to present the results and Chi-square test was performed for testing the association of the selected attributes with the high performance male and female students. Mann-Whiteny U test was used to compare the significant difference in the factors describing behavior of high performance male and female students regarding their studies. The results of MAS indicate that student’s involvement in their studies, quality of study, role conflict, relationship with the fellows, autonomy in their studies and environmental indulgence would affect the performance of the top most male and female students enrolled at university level education. Similarly, a significant (P 0.05). Similarly, peers relationship and autonomy in the study, the mean rank of high performance male students was higher than the female counterparts. Furthermore, the mean rank of high performance male students for autonomy in their studies was significantly (P