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Myofibroblast-mediated Contraction.

Author(s)
Wael M. Al Kattan Department of Surgery, Alfaisal University, Riyadh, Saudi Arabia
Seham F. Alarfaj Department of Surgery, King Saud University, Riyadh, Saudi Arabia
Bayan M. Alnooh Department of Surgery, King Saud University, Riyadh, Saudi Arabia
Hadeel F. Alsaif Department of Surgery, King Saud University, Riyadh, Saudi Arabia
Hayfa S. Alabdul Karim Department of Surgery, King Saud University, Riyadh, Saudi Arabia
Noha M. AlQattan Department of Obstetrics, King Saud University, Riyadh, Saudi Arabia
Amel A. F. El Sayed Department of Surgery, King Saud University, Riyadh, Saudi Arabia
Mohammad M. Al Qattan Department of Surgery / Obstetrics3, King Saud University,Riyadh, Saudi Arabia.
Abstract
Myofibroblast-mediated contraction is viewed as a cycle of four steps. The first step is stimulation of myofibroblasts by lysophospholipids leading to the activation of G proteins and ending with contraction of the actin-myosin complex. The next step is the transmission of the intracellular contractile force at the focal adhesions of myofibroblasts; a step that involves talin, vinculin, paxillin, Hic-5, and the integrin receptors. In the third step, fibronectin will act as the extracellular link between the integrin receptors and the extracellular collagen. Finally, “sensing” tension and the maintenance of myofibroblast activity represent the fourth step. The clinical relevance of each step is then discussed in the form of modalities to prevent excessive scarring/fibrosis.
Publication Details
Page(s) 38-43
DOI DOI not available
Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 27, Issue: 1, Year: 2017

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Keywords
Myofibroblast. Contraction. Fibrosis. Wound healing
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