Frequency of Hyperuricemia in Thyroid Dysfunction.

Sanober Hameed; Najam Us Sahar; Rizwan Hashim; Aisha Ayyub; Salman Ali

Author(s)

Sanober Hameed Army Medical College/ National University of Medical Sciences (NUMS) Rawalpindi, Pakistan

Najam Us Sahar Military Hospital/ National University of Medical Sciences (NUMS) Rawalpindi, Pakistan

Rizwan Hashim Army Medical College/ National University of Medical Sciences (NUMS) Rawalpindi, Pakistan

Aisha Ayyub Army Medical College/ National University of Medical Sciences (NUMS) Rawalpindi, Pakistan

Salman Ali Army Medical College/ National University of Medical Sciences (NUMS) Rawalpindi, Pakistan

Abstract

Objective: To determine the frequency of hyperuricemia in patients with thyroid dysfunction. Study Design: Cross-sectional descriptive study. Place and Duration of Study: Department of Chemical Pathology, Army Medical College Rawalpindi, National University of Sciences & Technology (NUST) Islamabad and Military Hospital (MH) Rawalpindi, from Apr 2013 to Jun 2014. Material and Methods: Fifty five individuals with thyroid dysfunction were included in this study. Detailed history was recorded on a questionnaire, blood samples were collected and serum total tri-iodothyronine (T3), free thyroxine (T4), thyroid stimulating hormone (TSH) and uric acid levels were measured. Results: Among the fifty five participants, 16 (29.1%) were male while 39 (70.9%) were females. Mean age of the subjects was 45.49 ± 16.7 years in this study. Hyperuricemia was observed in seventeen (30.9%) individuals with thyroid dysfunction. Mean serum uric acid level was found to be 418.3 ± 147 µmol/l in participants. Conclusion: High frequency of hyperuricemia occurs in patients with thyroid dysfunction. Therefore in patients presenting with thyroid dysfunction, evaluation of underlying hyperuricemia should be considered by the clinicians.

Publication Details

Page(s) 585-588

DOI DOI not available

Published Journal: Pakistan Armed Forces Medical Journal, Volume: 68, Issue: 3, Year: 2018

Request the full text from PASTIC

References

RodriguesSL,BaldoMP,CapinganaP,MagalhaesP,DantasEM,Molina MdelC, 2012.Gender distribution of serum uric acid and cardiovascular risk factors: population based study,Arq Bras Cardiol 98 13 -21

PasalicD,MarinkovicN,Feher-Turkovic L, 2012.Uric acid as one of the important factors in multifactorial disorders--facts and controversies,Biochem Medic 22 63 -75

GustafssonD,UnwinR., 2013.The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality,BMC Nephrol 14 164 -

AhsanN,ZuberiNA,AlamSM,EffendiJS,TunioSA, .Association of high serum uric acid with risk factors of cardiovascular disease in the rheumatology clinic of a tertiary care hospital of Karachi, 19 10 -4

WedaatallaMA,AbdellaAM, 2012.Assessment of plasma uric acid level among Sudanese female with thyroid dysfunction,Sudanese J Pub Health 7 89 -92

GiordanoN,SantacroceC,MattiiG,GeraciS,AmendolaA,GennariC, 2001.Hyperuricemia and gout in thyroid endocrine disorders,Clin Exp Rheumatol 19 661 -5

AjayKumar N., 2013.The Effect of L-Thyroxine on Metabolic Parameters in Newly Diagnosed Primary Hypothyroidism,Clin Exp Pharmacol 3 14 -18

SainiV,YadavA,AroraMK,AroraS,SinghR,BhattacharjeeJ, 2012.Correlation of creatinine with TSH levels in overt hypothyroidism-A requirement for monitoring of renal function in hypothyroid patients,Clin Biochem 45 212 -4

KhanAH,MajumderI., 2013.Serum creatinine and uric acid levels of hypothyroid patients,Bangla J Med Biochem 3 61 -3

de OliveiraEP,BuriniRC, 2012.High plasma uric acid concentration: causes and consequences,Diabetol Metabol Syndr 4 12 -

Al-RubaeSH,Al-MusawiAK, 2013.An evaluation of antioxidants and oxidative stress in Iraqi patients with thyroid gland dysfunction,African J Biochem Res 5 188 -96

AlhadithyAH,HassanSA, 2013.The association of thyroid dysfunction with the acute ischemic heart disease,Int J Adv Biol Res 3 249 -253

GencerB,ColletT-H,VirginiV,AuerR,RodondiN., 2013.Subclinical thyroid dysfunction and cardiovascular outcomes among prospective cohort studies,Endocr Metab Immune Disord Drug Targets 13 4 -12

ChenJH,ChuangSY,ChenHJ,YehWT,PanWH, 2009.Serum uric acid level as an independent risk factor for all‐ cause, cardiovascular, and ischemic stroke mortality: A Chinese cohort study,Arthritis Rheum 61 225 -32

TayalD,ChawlaR,AroraS,GuptaVK,SohiJS,MallikaV, 2009.Dynamic changes in biochemical markers of renal function with thyroid status-A study in Indian population,Internet J Med Update 4 36 -41

KhanMAH,MajumderMI,HoqueMM,FariduddinM,MollahFH,ArslanI., 2013.Serum creatinine and uric acid levels in hypothyroid patients: A cross sectional study,Bangla J Med Biochem 3 84 -7

AroraS,ChawlaR,TayalD,GuptaVK,SohiJS,MallikaV, 2009.Biochemical markers of liver and kidney function are influenced by thyroid function - A case-controlled follow up study in Indian hypothyroid subjects,Indian J Clin Biochem 24 370 -4