Ferrocene Derivatives: Potential Anticancer Material.

Asifa Nigar; Naveed Kausar janjua; Asghari Gul; Abid Ali; Zareen Akhter; Sadia Mehmood

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Ferrocene Derivatives: Potential Anticancer Material.

Author(s)

Asifa Nigar Department of Chemistry, Quaid-i-Azam University, Islamabad 45230, Pakistan

Naveed Kausar janjua Department of Chemistry, Quaid-i-Azam University, Islamabad 45230, Pakistan

Asghari Gul Department of Chemistry, Park Road Campus, COMSATS University, Islamabad 44000, Pakistan; Environment and Sustainability Institute (ESI), University of Exeter, Penryn Campus, Penryn, Cornwall TR10 9FE, United Kingdom.

Abid Ali Department of Chemistry, Quaid-i-Azam University, Islamabad 45230, Pakistan

Zareen Akhter Department of Chemistry, Quaid-i-Azam University, Islamabad 45230, Pakistan

Sadia Mehmood Department of Chemistry, Quaid-i-Azam University, Islamabad 45230, Pakistan

Abstract

Summary: The presented work is focused on the investigation of ferrocene and its derivatives (ferrocene benzoic acid and ferrocene dicarboxylic acid) via electrochemical, and spectrophotometric for biological activity. DNA binding capacity was studied by cyclic voltammetry and UV-Vis spectroscopy with evaluation of kinetic and thermodynamic parameters. Heterogeneous rate constant and diffusion coefficients were estimated for pure compounds and the compound bound with ds.DNA (double-stranded DNA). The voltammetric investigation suggested that the interaction between the ferrocene derivatives and ds.DNA was present. Oxidation potential (Ep) values showed that the interactions of ferrocene dicarboxlic acid (FC-2) with ds.DNA was stronger than that of ferrocene benzoic acid (FC-1). Diffusion coefficient and heterogeneous rate constant values also corresponded to the structural dependent interactions of these compounds with ds.DNA.

Publication Details

Page(s) 1046-1053

DOI DOI not available

Published Journal: Journal of Chemical Society of Pakistan, Volume: 40, Issue: 6, Year: 2018

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