About 10 million Pakistani population is infected with Hepatitis C virus (HCV). The prevalence is even more pronounced among high risk population. The commonest mode of transmission is the use of injections, unsterilized needles and contaminated instruments. Combination of standard interferon and ribavirin is still the first line therapy with sustained viral response (SVR) up to 40-50%. Pool of relapsers and non- responders is increasing inPakistanand needs treatment with pegylated interferon plus ribavirin (peg IFN/RIB). Pegylated interferon has limited use due to being costly. Efficacy of pegylated interferon in genotype 3 is still debatable. HCV related end stage liver disease and hepatocellular carcinoma (HCC) is a major cause of morbidity and mortality in health care settings ofPakistancausing exponential burden on financial health care resources.