Propofol Auto-coninduction Versus Midazolam Propofol Coninduction; a Comparative Study Applying Priming Technique.

Ammar Ali Shah; Latif Abid; Ayesha Nazir; Zubair Tariq; Farah Naz

Author(s)

Ammar Ali Shah Holy Family Hospital, Rawalpindi, Pakistan

Latif Abid Holy Family Hospital, Rawalpindi, Pakistan

Ayesha Nazir Holy Family Hospital, Rawalpindi, Pakistan

Zubair Tariq National Health Service (NHS), England, UK

Farah Naz Holy Family Hospital, Rawalpindi, Pakistan

Abstract

OBJECTIVE: To assess the applicability of priming technique in case of anesthetic agents propofol and midazolam. STUDY DESIGN: A Randomized controlled trial. PLACE AND DURATION: Department of Anaesthesiology and Intensive Care, Holy Family Hospital, Rawalpindi from 1st of January 2016 to 30th June 2016. METHODOLOGY: Current study had ninety participants divided equally in 3 groups with equal number of patients. Group I was given 0.5 mg/kg propofol intravenously which was about twenty percent of the worked out dose of propofol for anesthesia induction. Group II was injected 0.05 mg / kg intravenous midazolam while Group III was injected 3 ml 0.9 % saline, which was succeeded two min afterwards in all the groups with intravenous propofol injection till the loss of corneal reflex. Hemodynamic variables systolic blood pressure, diastolic blood pressure and mean arterial blood pressure were noted. RESULTS: The results showed a statistically significant reduction in the dosage requirement of induction agents. Induction dosage worked out to be 23.65% lower in the Group I (propofol auto-coinduction group) and 12.87% lesser in the Group II (midazolam coinduction group) in comparison to the control. The hemodynamics remained more stable in Group II (midazolam propofol coinduction group) during per intubation period. CONCLUSIONS: The principal of co-induction was found to be efficacious in terms of anesthesia induction agents propofol and midazolam.

Publication Details

Page(s) 201-204

DOI DOI not available

Published Journal: Isra Medical Journal, Volume: 9, Issue: 4, Year: 2017

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