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Imatinib quantification by liquid chromatography ultraviolet detection for monitoring of plasma levels.

Author(s)
Sameh Trabelsi Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigi lance, 9 Avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia
Hanene Eljebari Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigi lance, 9 Avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia
Amna Kooli Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigi lance, 9 Avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia
Emna Gaies Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigi lance, 9 Avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia
Rim Sahnoun Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigi lance, 9 Avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia
Nadia Jebabli Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigi lance, 9 Avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia
Mohamed Lakhal Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigi lance, 9 Avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia
Anis Klouz Laboratoire de Pharmacologie Clinique, Centre National de Pharmacovigi lance, 9 Avenue Dr. Zouheir Essafi, 1006 Tunis, Tunisia
Abstract
Imatinib is a new anticancer agent which acts by selectivity inhibiting the AN tyrosine kinase and has a striking antitumor activity in patient with chronic myelogenous leukemia (CML). In this study a rapid and sensitive High Pressure Liquid Chromatography (HPLC) method has been developed with UV detection for estimation of Imatinib from the plasma of CML patients. Samples were prepared in a simple and single step by precipitation of plasma proteins with methanol. Calibration plots in spiked plasma were linear in a concentration range of 500-4000 ng/mL. Inter and intra-day coefficient of variation (precision) and bias (accuracy) were
Publication Details
Page(s) 21-26
DOI DOI not available
Published Journal: Pakistan Journal of Scientific and Industrial Research (Series A: Physical Sciences), Volume: 55, Issue: 1, Year: 2012

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