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Dicliptera bupleuroides: An imperative source for protection from oxidative stress.

Author(s)
Tauheeda Riaz Department of Chemistry, Government College University, Lahore-54000, Pakistan
Muhammad Athar Abbasi Department of Chemistry, Government College University, Lahore-54000, Pakistan
Aziz-Ur-Rehman Department of Chemistry, Government College University, Lahore-54000, Pakistan
Tayyaba Shahzadi Department of Chemistry, Government College University, Lahore-54000, Pakistan
Muhammad Zahid Qureshi Department of Chemistry, Government College University, Lahore-54000, Pakistan
Muhammad Ajaib Department of Botany, Government College University, Lahore-54000, Pakistan
Abstract
Dicliptera bupleuroides Nees. has long been used in folkloric medicines for the treatment of various ailments. In this study, the methanolic extract of this plant was dissolved in distilled water and partitioned with n-hexane, chloroform, ethyl acetate and n-butanol sequentially. These organic fractions and the remaining aqueous fraction were tested for their phyto-constituents and antioxidant potential by four methods: 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity, total antioxidant activity, ferric reducing antioxidant power (FRAP) assay and ferric thiocyanate assay along with the determination of their total phenolic contents. The results revealed that among these fractions the chloroform soluble fraction and ethyl acetate soluble fraction showed good antioxidant potential. Their IC50 values were found to be 108.82±1.14 and 110.58±0.60 µg/mL respectively. Ethyl acetate soluble fraction showed highest total antioxidant activity i.e. 1.149±0.21. Chloroform and ethyl acetate soluble fractions also showed good FRAP values (227.56±1.27 and 213.43±1.16 TE µM/mL respectively) as well as considerable amounts of total phenolic compounds i.e. 123.17±1.33 and 115.16±1.09 GAE µg/g) and good values of percentage of inhibition of lipid peroxidation i.e. 42.17±0.79% and 41.14±1.46% respectively almost equal to each other. So, these fractions are useful potentially against the oxidative stress as compared to other studied fractions.
Publication Details
Page(s) 326-332
DOI DOI not available
Published Journal: Journal of Chemical Society of Pakistan, Volume: 34, Issue: 2, Year: 2012

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