Pakistan is a flood prone country and suffers from medium to high floods almost every year. The structural countermeasures have been taken time and again but due to destabilized economic condition of the country it is not possible to invest bulk amount of money for the flood control. In this study, an attempt is made to develop the nonstructural countermeasures for the downstream reach of the Indus River so that the losses and damages due to flooding could be minimized to the lowest level. The precise and timely flood forecast and warning play vital role in saving the lives and movable properties of the community. An early flood forecast provides sufficient lead time to rescue team and flood fighting agencies for necessary action to protect the embankment. A number of structural and non-structural measures including the Delft Hydraulic flood forecasting model (FEWS) have been adopted for the flood forecasting of the Indus River but the flood 2010 has washed away all of these efforts and demanded for the concrete solution-oriented flood forecasting model. Considering all the previous devastating floods and nonstructural measures adopted to mitigate the damages, an attempt has been made to implement the Integrate Flood Analysis System (IFAS) for the flood forecasting of the Indus River. The discharge data of different locations of the Indus River and the corresponding rainfall data of the upper catchment areas have been analyzed especially for the devastating flood 2010 carefully to check the feasibility of IFAS for the flood forecasting of the Indus River. In this study the IFAS has been regionally parameterized for the flood forecasting of the Indus River. This regionally parameterized IFAS has the capability to generate sufficient lead time forecast for the local population of the Indus River. This model is practically helpful for the flood early warning and to save the lives and properties of the Community.