Performance of irrigation systems is central to the success and sustainability of irrigated agriculture and well-being of the rural population in the developing countries. Indus irrigation System is the largest contiguous irrigation system in the World. It serves as lifeline for the irrigated agriculture and agro- based economy of Pakistan. In the recent past, the declining performance of the system has drawn the attention of many national and international agencies. This paper presents major issues and constraints which hamper the system performance in the country, and identifies the options and opportunities to overcome or face these constraints. It discusses the significance and applicability of various structural measures and management interventions to help recommend a set of measures to be implemented by various agencies user groups for improvement of irrigation system of this country, it also brings out the need to review the irrigation performance in the context of design parameters and objectives. Though it recognizes the weaknesses and gaps in the system performance but also portrays optimism regarding the future improvements in the irrigation system performance provided the problems are approached in a rational and systematic manner.