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Phenytoin Dosage Prediction.

Author(s)
A. H. Sawas Medical Science Department, Umm Al-Qura University, Makkah Al-Mukarramah, Saudi Arabia
A. M. N. Sultan Medical Science Department, Umm Al-Qura University, Makkah Al-Mukarramah, Saudi Arabia
M. H. Amasha Mental Health Hospital, Taif, Saudi Arabia
Abstract
259 serum samples of 58 Saudi epileptic patients treated by phenytoin as single therapy have been used to determine Vmax and Km of phenytoin and to study its dosage prediction. Bayesian feedback and Wagner methods have been compared with Michaelis Menten Linear transformation methods for prediction of phenytoin dosage. Hanes Woolf plot vs S), and Lineweaver-Burk (: vs ) followed by Bayesian method are best for phenytoin dosage prediction. Wagner method and other Michaelis-Menten linear transformation methods resulted in higher error.
Publication Details
Page(s) 39-48
DOI DOI not available
Published Journal: International Journal of Pharmacology, Volume: 9, Issue: 2, Year: 1992

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