Enhanced memory function in young rats following ascorbic acid administration.

Sadia Saleem; Saida Haider; Syeda Madiha; Saba Siddiqui; Sidra Mansoori; Darakhshan J Haleem

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Enhanced memory function in young rats following ascorbic acid administration.

Author(s)

Sadia Saleem Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan

Saida Haider Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan

Syeda Madiha Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan

Saba Siddiqui Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan

Sidra Mansoori Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan

Darakhshan J Haleem Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan

Abstract

The phenomenon of aging is associated with different variations in physiological, behavioral and neurochemical processes The aging brain goes through a considerable amount of alterations resulting in changes in neuronal structure and functioning that finally leads to cognitive impairment Ascorbic acid is the major water-soluble antioxidant and acts as a first defence against free radicals in plasma and brain and thus prevents onset of aging The aim of present study was to evaluate the antioxidant effects of ascorbic acid in growing rats Twelve young (3-4 months) female rats were taken and randomly assigned into Control (saline 09% injected) and test groups (50 mg/kg ascorbic acid injected Intraperitoneally ip) for 4 weeks The learning and memory of rats were assessed by passive avoidance (PA) test Locomotor activity of rats was monitored by open field test and anxiety was monitored in light/dark transition test Food intake and growth rate were also monitored daily for 4 weeks Results of behavioral tests showed significant (p

Publication Details

Page(s) 94-98

DOI DOI not available

Published Journal: Pakistan Journal of Biochemistry and Molecular Biology , Volume: 45, Issue: 2, Year: 2012

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