A new differential potentiometric technique based on a simple, inexpensive RC filter circuit, capable of producing primary derivative signals, is presented for quantitative differential potentiometric work. The relevant experimental set-up to carry out automatic potentiometric titrations is designed and Its performance is demonstrated for various weak-/strong acid-base combinations. The technique has the potential of application to other areas of potentiometric estimation such as compleximetry and redox titrimetry. The overall average accuracy of the method when applied to a set of 16 acid-base combinations turns out to be about 1.516 with a precision of 1% in duplicate runs.