The first Line Agents are regarded as Isoniazid, Rifampicin and Ethambutol along with streptomycin and pyrazinamide. Second Line Agents are Ethioneamide, Paraamino acid, Capreomycin, Kanamycin and Cycloserine. The second line drugs have more side effects than the first line drugs and do not have as much efficacy and potency. Latest research has focused on the prospects of Rifabutin, Clofazimine, Ofloxacin and Ciprofloxacin in antituberculous therapy.