Effect of some herbicides like Dicuran MA-60, DMA-6, Buctril-M, Banvel-P, Tribunil-wp. 70, Arelon Wp, 2, 4-D and control were investigated on weed population and growth of wheat cultivar Pak-81. The treatments were applied at two stages namely seedling and tillering of the crop. Comparing the plots before herbicidal application, no significant variation was observed in weed population whereas after the herbicidal application, this difference was significant not only within the treatments but between the crop stages as well. Weeds were most effectively controlled in plots applied with Arelon, Dicuran MA-60, Banvel-P, and. Tribunal 70 wp in decending order of efficiency. The chemicals however, did not significantly influence the number of tillers, spikelets per spikes 1000 grain weight and straw yield at both the stages of the crop.