The exact size of the normal eye ball is not known, even the small eye in hypermetropia and large in myopia is taken as normal. Similarly, in abnormal conditions some time it is difficult to distinguish e.g., anophthalmos from extreme degree of microphthalmos. Therefore, embryological classifications of defects are helpful to establish the differentiation of various clinical entities. The complete failure of primary optic vesicle to bud out is called primary anoph-thalmos i.e., the_ orbit is present without even a rudiment of the eye. Usually anophthalmos is of secondary nature where vesicle has formed but involuntary and degenerative changes overcome its development. Some cases show micro-phthalmos on one side and anophthalmos on the other, the latter being of congenital variety. A case is presented of a fathily with a combination of these conditions.