The notion that the physian has no concern with the mental disorders has now proved to be faulty in the light of the fact that many psychiatric troubles are linked with the disturbed metabolism or give rise to development of syndromes. Physiology and especially biochemistry have been able to throw a good deal of light on mental disorder. Abnormal physical signs and their interpretation in terms of visible lesions are the foundation upon which clinical medicine especially neurology has been placed. Twisted thoughts should be as much a physian`s concern as absent jerks.