Synthesis of some immunosuppressive agents.

Zafar S Saify; J Walker; Hilal A Shaikh; P. Q. R. Siddiqui

No Detail Found!

Synthesis of some immunosuppressive agents.

Author(s)

Zafar S Saify Pharmacy & Physiology Department, University of Karachi, Karachi, Pakistan

J Walker Pharmacy & Physiology Department, University of Karachi, Karachi, Pakistan

Hilal A Shaikh Pharmacy & Physiology Department, University of Karachi, Karachi, Pakistan

P. Q. R. Siddiqui Pharmacy & Physiology Department, University of Karachi, Karachi, Pakistan

Abstract

Since the tissue rejection phenomena after a surgical transplant has become a more serious problem in the recent years, an attempt was made to synthesize a few derivatives of 7-azaindole which could be used as immunosuppressive agents. The results showed that out of the three compounds prepared, only one had a moderate immunosuppressive activity It was, therefore, concluded that the polar nature of the compounds had rendered them to be non-diffusible across the cell membrane and thus to their negative activity.

Publication Details

Page(s) 131-134

DOI DOI not available

Published Journal: Journal of science, Volume: 2, Issue: 2, Year: 1973

Request the full text from PASTIC