The cholera vibrio multiplies in` the small intestine and releases an exotoxin which binds itself to the intestinal surface. The basic feature is the profuse loss of water and electrolytes from the tissues. The electrolyte content of the cholera stool is almost identical to that of normal intestinal secretion. Besides, dehydration from the severe fluid and electrolyte depletion, there is metabolic acidosis due to loss of bicarbonate in the faeces. If uncorrected, the acidosis leads to severe pulmonar oedema. No pathological lesions specific to cholera have been demonstrated. A significant finding, which has helped in the current understanding of the pathogenesis of cholera, is the intact intestinal epithelium-oral glucose-electrolyte solution in the treatment elves goad results.