Gives brief description of some of the pecularities of liver and the role played by this organ in drug therapy. Mentions the usual liver damage caused in combating with the complex synthetic oral medicines. Enumerates direct and indirect hepatotoxins. The direct hepatotoxins cause parenchymal changes with or without jaundice or chloestasis. Common agents causing haemotytic Jaundice are cited. Also hints the diagnosis of liver damage. Gives precautions to be observed while prescribing hepatotoxic drugs.