The present diagnostic tests for cancers are expensive and are not accessible by poor. Therefore, it was necessary to explore a diagnostic test accessible by general public. Plasma lipid profile is decreased in all the cancers except in breast cancer, where HDL-cholesterol is decreased while the other lipids are increased. Therefore, plasma lipid profile may be used as diagnostic test for malignancy. As general diagnostic procedures, these laboratory parameters (plasma lipids) should also be co-related with the clinical symptoms of the patient and other diagnostic tools.