Diabetes Mellitus is a global health problem. Uncontrolled diabetes affects T cell and B cell function, causing increased predisposition to bacterial infections. Increased susceptibility to infections may precipitate metabolic complications in diabetes. Awareness of diabetes related diseases helps in early mitigation of symptoms and reduces morbidity. Diabetes education, along with optimal glycaemic control, can minimize the risk of life threatening infections. Appropriate choice of empirical antibiotics can limit the severity of symptoms. Immunization with influenza and pneumococcal is often recommended. Complicated cases should be referred for specialist consultations.