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Tumour induced osteomalacia.

Author(s)
Muhammad Qamar Masood Section of Endocrinology, The Aga Khan University Hospital, Karachi, Pakistan
Nanik Ram Section of Endocrinology, The Aga Khan University Hospital, Karachi, Pakistan
Syed Ahsan Ali Section of Internal Medicine, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
Abstract
Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome usually presenting with bone pain, fracture of bones and muscle weakness. It is caused by high serum levels of fibroblast growth factor 23 (FGF- 23), which is a hormone-regulating phosphate, and vitamin D. FGF-23 is secreted by several tumours, especially benign mesenchymal tumours which are very small and difficult to locate. There is a significant delay from onset of symptoms to the diagnosis of this entity due to occult nature of this disease. We present a case of young male who presented with long history of progressively worsening muscular pain and weakness, rendering the patient confined to bed. Our aim of presenting this patient as a case report is to make physicians realise that any patient with unexplained muscular weakness and pain must undergo workup for TIO, including serum phosphate measurement, as this is a rare but potentially curable disease.
Publication Details
Page(s) 220-222
DOI DOI not available
Published Journal: Journal of Pakistan Medical Association, Volume: 65, Issue: 2, Year: 2015

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