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Temozolomide for treating malignant melanoma.

Author(s)
Rong Hua Li Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China
Xiao Yang Hou Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China
Chun Sheng Yang Department of Dermatology, Affiliated Huai`an Hospital of Xuzhou Medical College, Huai`an, China
Wen Lou Liu Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China
Jian Qin Tang Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China
Yan Qun Liu Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China
Guan Jiang Department of Dermatology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, China
Abstract
Melanoma is one of the most malignant forms of skin cancer; with a rapidly increasing prevalence. Early-stage melanoma is curable, but advanced metastatic melanoma is almost always fatal, and patients with such advanced disease have short median survival. Surgery and radiotherapy play a limited role in the treatment of metastatic melanoma. Rather, chemotherapy remains the mainstay of treatment, although other approaches, including biotherapy and gene therapy, have been attempted. The authors hereby, evaluated the use of temozolomide (TMZ) for treating metastatic melanoma compared to dacarbazine (DTIC), the effectiveness of TMZ for treating brain metastases, as well as TMZ resistance and how the efficacy of TMZ in malignant melanoma can be increased. Two chemotherapeutic regimens are commonly used for palliative treatment of malignant melanoma: intravenous administration of DTIC and oral administration of the alkylating agent temozolomide (TMZ). Compared to DTIC, TMZ is very well tolerated and has an advantage in terms of improving the quality of life of patients with metastatic melanoma. While the prognosis is currently unpromising, chemotherapy plays a palliative role for patients with metastatic melanoma. The toxicity of treatment regimens based on DTIC and TMZ do not differ significantly, although TMZ is costlier. These findings provide a reference for future researchers via a comprehensive analysis of the relevant literature., DEBATE.
Publication Details
Page(s) 680-688
DOI DOI not available
Published Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 25, Issue: 9, Year: 2015

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