Bioactive phenolics from Launaea intybacea

SHEHLA PARVEEN; NAHEED RIAZ; Muhammad Saleem; JALLAT KHAN; SHABIR AHMAD; Muhammad Ashraf; SYEDA ABIDA EJAZ; RASOOL BAKHSH TAREEN; ABDUL JABBAR

SHEHLA PARVEEN Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan

NAHEED RIAZ Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan

Muhammad Saleem Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan

JALLAT KHAN Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan

SHABIR AHMAD Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan; Department of Chemistry, Government Post-graduate College, Baghdad Road, Bahawalpur, Pakistan

Muhammad Ashraf Department of Biochemistry Biotechnology, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan

SYEDA ABIDA EJAZ Department of Pharmacy, Khawaja Fareed Campus, The Islamia University of Bahawalpur, Pakistan

RASOOL BAKHSH TAREEN Department of Botany, Baluchistan University Quetta, Pakistan

ABDUL JABBAR Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Pakistan

Phytochemical investigations on the methanolic extract of Launaea intybacea yielded eleven compounds namely, octadecyl (E)-p-coumarate (1), 4-hydroxy-3-methoxybenzaldehyde (2), 4-hydroxybenzoic acid (3), 4-hydroxy-3-methoxybenzoic acid (4), coumaric acid (5), methyl gallate (6), 3,4-dihydroxybenzoic acid (7), 4,5,7-trihydroxyflavone (8), 3,4,5,7-tetrahydroxyflavone (9), 3,3,5,7-tetrahydroxy-4-methoxyflavone (10) and apigenin 7-O-(4-O-p-E-coumaroyl)-ß-D-glucopyranoside (11). Their structures were determined by using 1D-NMR (1H, 13C), mass spectrometry (EIMS, HREIMS, FABMS, HRFABMS) and comparison with the reported data. These compounds (1-11) showed DPPH radical scavenging and enzyme inhibitory activities.