Local anesthesia (anesthesia) is the reversible loss of sensation in a defined area of the body and is achieved by the topical application or injection of agents that block the generation and/or journey of nerve impulses in tissue. No dermatological procedure is possible without a local anesthetic. Local anesthesia is used in many dermatological procedures and surgical operations. The aim is to minimize pain and suffering and maximize patient comfort. This article provides an insight into the various types of anesthesia for dermatologic procedures and their complications.