No Detail Found!

Comparative function-structural analysis of antiplatelet and antiradical activities of flavonoid phytochemicals.

Author(s)
Chunmei Guo Department of Biotechnology, Department of General Surgery of The Second Hospital, Dalian Medical University, Dalian 116044, China
Yimeng Guo Department of Biotechnology, Department of General Surgery of The Second Hospital, Dalian Medical University, Dalian 116044, China
Yuling Yin Department of Biotechnology, Department of General Surgery of The Second Hospital, Dalian Medical University, Dalian 116044, China
Jintao Lin Department of Biotechnology, Department of General Surgery of The Second Hospital, Dalian Medical University, Dalian 116044, China
Xin Chen Department of Biotechnology, Department of General Surgery of The Second Hospital, Dalian Medical University, Dalian 116044, China
Ming-Zhong Sun Department of Biotechnology, Department of General Surgery of The Second Hospital, Dalian Medical University, Dalian 116044, China
Shuqing Liu Department of Biochemistry, Department of General Surgery of The Second Hospital, Dalian Medical University, Dalian 116044, China
Abstract
The antiplatelet and antiradical activities of 8 dietary flavonoid phytochemicals were investigated and compared. Quercetin, rutin, isoquercitrin, hesperetin, naringenin, hesperidin, naringin and icariin inhibited ADP-induced rat platelet aggregation by 68.33±2.43%, 55.34±2.09%, 52.27± 4.65%, 50.80±7.03%, 33.07±2.09%, 31.28±4.65%, 22.91±1.68% and 20.94±3.20%, respectively. Only quercetin, rutin and isoquercitrin showed clear scavenging HO· radical activity. Function-structure analysis indicated 1) flavonoids with more free phenolic hydroxyl groups showed relative higher antiplatelet and antiradical activities; 2) substitution of 7-OH of A ring affected antiplatelet capacities of flavanones apparently; 3) free 3-OH of C ring was important for both the antiplatelet and antiradical activities of flavonol (quercetin) and flavones (rutin, isoquercitrin); 4) C ring C2-C3 double bond and B ring 3’-4’orthodihydroxy might be important for its antiradical function. This study provides certain clues for evaluating a favorable dietary flavonoid drugs from our foods in prevention and treatment of related diseases associated with platelet aggregation and hyroxyl radical oxidation.
Publication Details
Page(s) 926-935
DOI DOI not available
Published Journal: Journal of Animal and Plant sciences, Volume: 24, Issue: 3, Year: 2014

Request the full text from PASTIC

More from Journal of Animal and Plant sciences
0

Citations

0

Downloads

57

Views

Copyright ©  PASTIC National Center, Islamabad www.pastic.gov.pk