Objective: To analyse the indications, frequency and outcomes of open partial cholecystectomy in comparison with complete cholecystectomy during surgery. Material & Methods: A retrospective descriptive study was performed at the Department of Surgery, Baqai Medical University Hospital, Nazimabad, Karachi from April 2007 to April 2012. A total number of 42 patients with gall stone disease, who underwent partial cholecystectomy, were analysed. The case selection criteria was based preoperatively on history, clinical findings, ultrasound and CT scan examination. Final decision was made as per operative findings during open cholecystectomy. Results: Forty two (42) patients with gall stone disease underwent partial cholecystectomy. Age range was from 35 years to 80 years (Mean age: 47 years). Male and female ratio showed female preponderance .In our study, 62% patients had acute cholecystitis, 16.5% patients had empyema gall bladder, 9.5% patients had mucocele and 12% patients had gall stone acute pancreatitis.Tube Cholecystostomy was performed in two patients. Conclusion: Partial cholecystectomy is safe and effective procedure in difficult cases, with over all less complications and is almost equivalent to total cholecystectomy.