Subtotal thyroidectomy; changes in the thyroid autoantibody level following surgery and radioiodine therapy.

Khalilur-Rehman; Rizwan Hashim; Asmaa Qureshi; Muhammad Tayyab

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Subtotal thyroidectomy; changes in the thyroid autoantibody level following surgery and radioiodine therapy.

Author(s)

Khalilur-Rehman Department of pathology, King Edward Medical College, Lahore, Pakistan

Rizwan Hashim Combined Military Hospital, Lahore, Pakistan

Asmaa Qureshi King Edward Medical College, Lahore, Pakistan

Muhammad Tayyab Department of Pathology, Postgraduate Medical Institute, Lahore, Pakistan

Abstract

Objective: Autoimmunity is common in thyroid diseases. Antibody level is affected after subtotal thyroidectomy and radio iodine treatment. We studied microsomal & thyroglobulin autoantibody level in patients with toxic diffuse goitre and multinodular goitre before and after surgery and radio iodine to determine effects of therapy. Design: Prospective study. Settings: Postgraduate Medical Institute, Lahore. Material & Methods: Three serial blood samples from each of a total of 30 seropositive patients ( 15 of multinodular goitre, undergoing thyroid surgery. 15 of toxic diffuse goitre receiving radioiodine) were analyzed for microsomal & thyroglobulin autoantibody using tagged red cell haemagglutination technique. Results: We found a female preponderance in thyroid diseases. The microsomal & thyroglobulin autoantibody level in patients with multinodular goitre, decreased gradually and progressively after subtotal thyroidectomy while subjects with toxic diffuse goitre receiving radioiodine showed a rise in antibody level as compared to pretreatment period. The change became evident just after 10 days of therapy. Conclusion: The autoimmune status of thyroid disease patients is altered after subtotal thyroidectomy & radioiodine therapy. The autoantibody levels after subtotal thyroidectomy are gradually decreased while after radioiodine therapy the antibody levels have been found to increase.

Publication Details

Page(s) 16-21

DOI DOI not available

Published Journal: Professional Medical Journal, Volume: 11, Issue: 1, Year: 2004

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