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Fibrinolysis and coagulation in pre-eclampsia.

Author(s)
Imrana Ihsan Department of Physiology, Allama Iqbal Medical College, Lahore, Pakistan
Muhammad Akram Department of Physiology, Allama Iqbal Medical College, Lahore, Pakistan
Nayla Tariq Ch. Department of Physiology, Allama Iqbal Medical College, Lahore, Pakistan
Zafar Ali Ch. Department of Physiology, Allama Iqbal Medical College, Lahore, Pakistan
Abstract
The hyperactivation of clotting mechanisms in preeclampsia results in intravscular fibrin deposition with Activation of fibrinolytic system. This converts fibrin and fibrinogen into Fibrin Degradation Products (FDP). The assay of fibrin degradation products is a valid reflection of in vivo formed cross linked fibrin. This study was designed to assess levels of FDP in preeclampsia. For this purpose 50 normal pregnant and 50 preeclamptic women were included in the study at 24-36 weeks of gestation. A semiquantitative assay of FDP was performed on serum using sensitized latex particles with specific antibodies to fragments D and E. In 70% of the preeclamptic women FDP levels were high. The results suggests hyperactivity of fibrinolytic mechanism preeclampsia.
Publication Details
Page(s) 176-178
DOI DOI not available
Published Journal: Pakistan Postgraduate Medical Journal, Volume: 15, Issue: 4, Year: 2004

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