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Prostatic specific antigen levels among prostatic and non - prostatic carcinoma.

Author(s)
Anila Asghar Department of Biochemistry, Fatima Jinnah Medical College, Lahore, Pakistan
Nasreen Sharif Department of Biochemistry, Fatima Jinnah Medical College, Lahore, Pakistan
Arif Rasheed Malik Department of Forensic Medicine King Edward Medical College, Lahore, Pakistan
Amir Hamzo Department of Forensic Medicine King Edward Medical College, Lahore, Pakistan
Muhammad Tayyib Department of Pathology, Post Graduate Medical Institute, Lahore, Pakistan
Zafar Ali Ch. Department of Pathology, Post Graduate Medical Institute, Lahore, Pakistan
Farhat Zaheer Department of Biochemistry Lahore Medical University, Lahore, Pakistan
Abstract
Prostate-specific antigen (PSA) is a protein which is almost exclusively produced by the prostatic epithelium. Low concentrations of PSA are also produced by other tissues such as ovaries, breast, and adrenal and renal carcinomas. However, in clinical practice PSA is sufficiently specific for the prostate gland. PSA is organ-specific but not cancer-specific. In view of above, this study was carried out and the concentration of TPSA was measured in 120 subjects. Out of which 30 were diagnosed cases of prostate cancer, 40 were diagnosed cases of breast cancer, 25 were normal healthy males and 25 were normal healthy females. Blood samples were taken from patients of prostate & breast cancer before surgery. Beside TPSA, FPSA and PAP concentrations were also measured in prostate cancer patients. Concentrations of TPSA and FPSA were measured by IRMA while PAP activity was measured by colorimetric method. The range of age in prostate cancer patients was from 50 - 100 years with the maximum number of patients in the age group between 50 - 65 years. Mean TPSA and FPSA levels were raised among prostate cancer patients with the age below 75 years as compared to that of with the age above 75 years and these levels were maximum in the age group between 66-74 years. Only one patient of breast cancer had TPSA levels of 7.924 ng/ml. Mean TPSA level (0.114 t 00 ) among 39 breast cancer patients was significantly different from mean TPSA level (65.7 + 9.93) in prostate cancer patients.
Publication Details
Page(s) 117-123
DOI DOI not available
Published Journal: Pakistan Postgraduate Medical Journal, Volume: 15, Issue: 3, Year: 2004

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