This paper gives an insight into the effect of process parameters on the recovery of copper of the North Wazirstan (Pakistan). The study is based on the primary data with seven important variables, i.e type and dosage of collector (X1gms ton), PH (X2), depressant sodium cyanide (X3 gms/ton), sulfidizer Na2 S(X4gms/ton), frother dosage (X5 gms/ton), pulp density (X6w/v) and conditioning time (X7 minute). Thirty-one experimental tests were conducted by the Department of Mining Engineering NWFP University of Engineering and Technology, Peshawar. Flotation process parameters were studied to concentrate the copper content i.e. chalcopyrite of North Waziristan copper ore. Mathematical models were developed by applying Ordinary Least Squares (OLS) method for regression analysis and adopted general to simple modeling procedure. In this study it was that the variables X1, X3 X4 and X6 of equation (3) are statistically significant and concluded that with an increase in these variables there is increase in recovery of copper.