Tree nuts supplementation instigates the oxidative status and improves brain performance in male rats

Faiza Agha; Zehra Batool; Tuba Sharf Batool; Rida Nisar; Fizza Naqvi; Sadia Saleem; Irfan Sajid; Saida Haider

doi:10.36721/PJPS.2020.33.6.SUP.2785-2791.1

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Tree nuts supplementation instigates the oxidative status and improves brain performance in male rats

Author(s)

Faiza Agha Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan;Department of Biochemistry, Liaquat National Medical College, Karachi, Pakistan

Zehra Batool Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Tuba Sharf Batool Atta-ur-Rehman School of Applied Biosciences, National University of Science and Technology,Islamabad,Pakistan

Rida Nisar HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi,,Pakistan

Fizza Naqvi Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan

Sadia Saleem Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan

Irfan Sajid Department of Biochemistry, Federal Urdu University of Arts, Science and Technology,Karachi,Pakistan

Saida Haider Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Pakistan

Abstract

Exposure to cadmium has been extensively increased due to its usage in modern daily life. Inside the human body it induces deteriorating effects in every vital organ including brain. Oxidative stress has been widely implicated in neurotoxicity induced by cadmium exposure. Consumption of dietary source of exogenous antioxidants is one of the recommended ways to extenuate heavy metal-induced oxidative stress. The potential of nuts against heavy-metal induced neurotoxicity has not been investigated earlier. This study was, therefore, conducted to find out the antioxidant ability of almond and walnut in the prevention of cadmium-induced oxidative stress. Rats were treated with nuts (400 mg/kg) daily for 28 days whereas, cadmium (50 mg/kg) was given once in a week. Brain function was monitored in terms of memory performance using Morris water maze and elevated plus maze. Moreover, oxidative stress status was also evaluated. Results showed that weekly exposure of cadmium significantly reduced %memory retention, increased lipid per oxidation and inhibited antioxidant enzymes activity. When nuts supplemented rats were monitored for these parameters, it was observed that almond and walnut have a great potential to reduce cadmium-induced neurotoxicity as evident by decreased oxidative stress and improved memory function in cadmium intoxicated rats.

Publication Details

Page(s) 2785-2791

DOI 10.36721/PJPS.2020.33.6.SUP.2785-2791.1

Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 33, Issue: SUP6, Year: 2020

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Keywords

Cadmium, walnut, almond, Oxidative stress, memory retention

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