Reference intervals for glomerular filtration function markers among pregnant women of Shandong Province, east China

Yanqiu Xu; Shiqing Cheng; Yan Su; Bin Liu; Fang Luan

doi:10.36721/PJPS.2020.33.5.SP.2445-2448.1

Author(s)

Yanqiu Xu Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University,Shandong,China

Shiqing Cheng Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University,Shandong,China

Yan Su Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University,Shandong,China

Bin Liu Department of Biomedical Engineering, Shandong Provincial Hospital affiliated to Shandong First Medical University,Shandong,China

Fang Luan Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University,Shandong,China

Abstract

The aim of the study was to establish reference intervals (RIs) for glomerular filtration function markers among pregnant women of Shandong Province, east China. From Janunary 2017 to December 2018, we retrospectively analyzed serum samples from 360 pregnant women and a control cohort of 60-non-pregnant women. The glomerular filtration function markers included Cystatin C (CysC), Creatinine (Cr) and Estimated Glomerular Filtration Rate (eGFR). BeckmanAU5800 detection system was used to determine the serological level of CysC by immunonephelometry method and Cr by enzyme method, eGFR was calculated according to age, gender and Cr results. We calculated the RIs according to the guidelines in C28-A3 published by the Clinical and Laboratory Standards Institute (CLSI). The calculated RIs for serum CysC were (0.40-0.67) mg/L, (0.5-0.85) mg/L, (0.77-1.49) mg/L in 1st, 2nd, and 3rd trimester respectively. Cr were (37.26-57.47) µmol/L, (33.70-54.82) µmol/L, (33.66-62.69) µmol/L in each cohort. eGFR based on Cr were (115.24-140.05) ml/min per 1.73m2, (117.42-141.88) ml/min per 1.73m2, (109.00146.00) ml/min per 1.73m2. The results show the necessity to establish special RIs for glomerular filtration function markers during pregnancy, even in each trimester. CysC levels increase obviously, so we also should cautiously treat it in the three trimesters.

Publication Details

Page(s) 2445-2448

DOI 10.36721/PJPS.2020.33.5.SP.2445-2448.1

Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 33, Issue: S5, Year: 2020

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Keywords

Cystatin C, Reference intervals, Glomerular filtration rate, Creatinine, Pregnancy

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