Simultaneous quantification of sumatriptan succinate and prochlorperazine maleate in orodispersible films using two validated UV-spectroscopic methods

Sana Javed; Amjad Hussain; Pervaiz Akhtar Shah; Saiqa Ishtiaq; Ejaz Ali; Nasir Abbas; Nadeem Irfan Bukhari

doi:10.36721/PJPS.2022.35.1.SUP.183-194.1

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Simultaneous quantification of sumatriptan succinate and prochlorperazine maleate in orodispersible films using two validated UV-spectroscopic methods

Author(s)

Sana Javed Primary and Secondary Health Department, Government of the Punjab,,Pakistan;Punjab University College of Pharmacy, University of the Punjab,Lahore-,Pakistan

Amjad Hussain Punjab University College of Pharmacy, University of the Punjab,Lahore-,Pakistan

Pervaiz Akhtar Shah Punjab University College of Pharmacy, University of the Punjab,Lahore-,Pakistan

Saiqa Ishtiaq Punjab University College of Pharmacy, University of the Punjab,Lahore-,Pakistan

Ejaz Ali Punjab University College of Pharmacy, University of the Punjab,Lahore-,Pakistan

Nasir Abbas Punjab University College of Pharmacy, University of the Punjab,Lahore-,Pakistan

Nadeem Irfan Bukhari Punjab University College of Pharmacy, University of the Punjab,Lahore-,Pakistan

Abstract

The study aimed at simultaneous quantification of sumatriptan succinate (SUM) and prochlorperazine maleate (PCP) in an orodispersible film using two validated spectroscopic methods viz. simultaneous equation (Method I) and the Q-absorption ratio (Method II). The Method I involved measurement of absorbances at ?max of both drugs while in Method II, absorbances were measured at isosbestic wavelength and ?max of one of the two components. Method validation were accomplished as per the ICH guidelines. A 1:1 mixture of the drugs and an orodispersible film (ODF) containing these drugs were assayed by both methods. The absorbance data of SUM and PCP in both methods were linear at respective wavelengths with correlation coefficient values >0.995. Both methods were precise as % RSD in repeatability, interday and intraday precision was less than 2. The estimation of SUM and PCP from the film dosage form by method I was104.74% and 98.34% and by method II was 103.45% and 98.85%, respectively, with a standard deviation <2. The study concluded that both the methods were simple, reliable and robust and can be applied successfully for the simultaneous quantification of SUM and PCP in mixture and orodispersible film dosage form.

Publication Details

Page(s) 183-194

DOI 10.36721/PJPS.2022.35.1.SUP.183-194.1

Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 35, Issue: SUP1, Year: 2022

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Keywords

prochlorperazine maleate, simultaneous analysis, Method Validation, UV-visible spectroscopy, sumatriptan succinate

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