Five hexaploid bread wheat varieties, selected on the basis of morphological evaluation, were crossed in all possible combinations to test their combining ability and nature of gene action involved by using Griffing`s technique. Genotypes showed significant differences for all the characters. General Combining ability (GCA) variance was highly significant for all the characters except number of spikelets per spike. The variance was more than the specific combining ability (SCA), indicating additive gene effects for all the characters. However, variances for SCA and reciprocals were non-significant. Considering all the characters together, Inqlab 91 was good general combiner for 1000-grain weight and grain yield per plant. While highest value of SCA effects for grain yield per plant were recorded in the cross Chakwal 86 x Inqlab 91.