Essential hypertension.

Rizwan Ashraf; Imran Ashraf; Noor Kamil; Muhammad Shamaun Razi; Kausar Aamir; Imran Khan; Abdul-Mannan

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Essential hypertension.

Author(s)

Rizwan Ashraf Department of Pharmacology, Shifa College of Medicine, Islamabad, Pakistan

Imran Ashraf MRCP General Medicine, Queen Mary`s Hospital, Sidcup, Kent, London, UK

Noor Kamil Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Laboratory, University of Karachi, Karachi, Pakistan

Muhammad Shamaun Razi Department of Physiology, Shifa College of Medicine Islamabad, Pakistan

Kausar Aamir Jinnah Postgraduate Medical Center, Karachi, Pakistan

Imran Khan Ayub Medical College, Abbottabad, Pakistan

Abdul-Mannan Department of Nuclear Medicine, Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar, Pakistan

Abstract

Hypertension and type 2 Diabetes mellitus also tend to coexist. The goal of antihypertensive therapy should consist of reducing cardiovascular morbidity and mortality associated with hypertension by a strategy focused on lowering blood pressure while minimizing the impact on other associated cardiovascular risk factors like diabetes mellitus. Objectives: To observe and compare any change in serum glucose in patients with newly diagnosed essential hypertension with Atenolol and Amlodipine. Setting: Department of Pharmacology and Therapeutics, Basic Medical Science Institute (BMSI), Jinnah Post Graduate Medical Centre (JPMC), Karachi. Period: 12 weeks (90 days) Methods: Patients with newly diagnosed essential hypertension (N=70) were enrolled in this study and were divided into two groups, each comprised of 35 patients and were given tablet Atenolol 150/100mg once daily and tablet Amlodipine 5/10 mg once daily respectively for 90 days. Fasting Blood glucose was measured on day of inclusion i.e. day 0, day 45 and day 90. At each fortnightly visit, blood pressure was recorded. Results: Atenolol raised mean blood glucose levels from baseline levels of 91.82±1.34 mg/dl to 99.73±1.33 mg/dl on day 90 (P

Publication Details

Page(s) 627-633

DOI DOI not available

Published Journal: Professional Medical Journal, Volume: 14, Issue: 4, Year: 2007

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