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RUNX1 transcription repression and stability: Interplay between phosphorylation and ?OpS-G1cNAc modification.

Author(s)
Saira Anwar Malik Institute of Molecular Sciences & Bioinformatics, Lahore, Pakistan
Ishtiaq Ahmad Institute of Molecular Sciences & Bioinformatics, Lahore, Pakistan
Tehmina Saleem Khan Institute of Molecular Sciences & Bioinformatics, Lahore, Pakistan
Nasir-Ud-Din Institute of Molecular Sciences & Bioinformatics, Lahore, Pakistan
Abdul Rauf Shakoori School of Biological Sciences, University of the Pun jab, Lahore, Pakistan
Nasir-Ud-Din HEJ Research Institute of Chemistry, University of Karachi, Karachi and Institute of Management Sciences, Geneva, Switzerland
Abstract
RUNXI is a transcription factor that plays major role in hematopoeisis. RUNX1 activation is dependent on phosphorylation in its transactivation domain. Ser 249 and 276 are the potential sites for phosphorylation that lead to transcriptionally active RUNX1 which has transient action and is prone to proteasome mediated degradation. We propose that Ser 249 and 276 have the highest potential for O-GlcNAc modification, and are the Yin Yang sites (potential for both phosphorylation and O-G1cNAc modifications). In contrast to phosphorylation modification, 0-glycosylation modification of RUNX I leads to its transcriptional repression. This novel O-GlcNAc modification on RUNX 1 provides a mechanism for regulation of transcription activity and stability of RUNX1. OGT mediated O-GIcNAc modified RUNX1 is more stable and is resistant to proteasome mediated degradation.
Publication Details
Page(s) 299-309
DOI DOI not available
Published Journal: Pakistan Journal of Zoology, Volume: 39, Issue: 5, Year: 2007

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